Molecular genetic characteristics of lung cancer - useful as 'real' tumor markers?

被引:16
作者
Fleischhacker, M [1 ]
Beinert, T [1 ]
Possinger, K [1 ]
机构
[1] Univ Klinikum Charite, Med Klin & Poliklin Schwerpunkt Hamatol & Onkol, D-10117 Berlin, Germany
关键词
molecular genetic characteristics; lung cancer; tumor markers;
D O I
10.1016/S0169-5002(99)00043-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The increased knowledge about the molecular mechanisms leading to the development of a tumor has opened new horizons for basic and applied research. Lung cancer is among the tumor entities with the highest incidence and mortality rates. Recently new drugs and therapeutic options for patients with lung cancer were developed. These developments demand new and improved techniques for the sensitive and specific detection of lung tumor cells. Some of the molecular genetic features of lung tumor cells are summarized and the possibilities to use these characteristics as new tumor markers are discussed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:7 / 24
页数:18
相关论文
共 122 条
[61]   DETECTION AND SEQUENCING OF P53 GENE-MUTATIONS IN BRONCHIAL BIOPSY SAMPLES IN PATIENTS WITH LUNG-CANCER [J].
MITSUDOMI, T ;
LAM, S ;
SHIRAKUSA, T ;
GAZDAR, AF .
CHEST, 1993, 104 (02) :362-365
[62]  
Mitsudomi T, 1996, CLIN CANCER RES, V2, P1185
[63]  
Moll R, 1993, Veroff Pathol, V142, P1
[64]   Microsatellite alterations in serum DNA of head and neck cancer patients [J].
Nawroz, H ;
Koch, W ;
Anker, P ;
Stroun, M ;
Sidransky, D .
NATURE MEDICINE, 1996, 2 (09) :1035-1037
[65]  
Nelson HH, 1998, CANCER RES, V58, P1804
[66]   DIAGNOSIS OF MICROMETASTASES BY THE AMPLIFICATION OF TISSUE-SPECIFIC GENES [J].
NEUMAIER, M ;
GERHARD, M ;
WAGENER, C .
GENE, 1995, 159 (01) :43-47
[67]   Micrometastatic tumor cells in the bone marrow of patients with non-small cell lung cancer [J].
Ohgami, A ;
Mitsudomi, T ;
Sugio, K ;
Tsuda, T ;
Oyama, T ;
Nishida, K ;
Osaki, T ;
Yasumoto, K .
ANNALS OF THORACIC SURGERY, 1997, 64 (02) :363-367
[68]  
Orfanidou D, 1998, ONCOL REP, V5, P763
[69]   RAPID AND SENSITIVE DETECTION OF POINT MUTATIONS AND DNA POLYMORPHISMS USING THE POLYMERASE CHAIN-REACTION [J].
ORITA, M ;
SUZUKI, Y ;
SEKIYA, T ;
HAYASHI, K .
GENOMICS, 1989, 5 (04) :874-879
[70]   DIFFERENTIAL EXPRESSION OF PROLIFERATION-ASSOCIATED MOLECULES IN INDIVIDUAL MICROMETASTATIC CARCINOMA-CELLS [J].
PANTEL, K ;
SCHLIMOK, G ;
BRAUN, S ;
KUTTER, D ;
LINDEMANN, F ;
SCHALLER, G ;
FUNKE, I ;
IZBICKI, JR ;
RIETHMULLER, G .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (17) :1419-1424