Improved protocol towards isotopically labelled 1-deoxy-D-xylulose

被引:19
作者
Jux, A [1 ]
Boland, W [1 ]
机构
[1] Max Planck Inst Chem Ecol, D-07745 Jena, Germany
关键词
D O I
10.1016/S0040-4039(99)01417-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An improved synthetic protocol towards 1-deoxy-[4,4-H-2(2)]-D-xylulose (1a) (= 1-deoxy-[4,4-H-2(2)]-D-threopentulose) from dimethyl 2,3-O-isopropylidene-o-tartrate (2) (44% overall yield) is described. The key-operation is a novel one-pot reductive alkylation of the protected halfester 3, by sequential treatment with superdeuteride(hydride) and methyl lithium, providing the protected 1-deoxy-D-xylulose (5) in high yield. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:6913 / 6914
页数:2
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