Improved protocol towards isotopically labelled 1-deoxy-D-xylulose

被引：19

作者：

Jux, A ^{[1
]}

Boland, W ^{[1
]}

机构：

[1] Max Planck Inst Chem Ecol, D-07745 Jena, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(99)01417-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved synthetic protocol towards 1-deoxy-[4,4-H-2(2)]-D-xylulose (1a) (= 1-deoxy-[4,4-H-2(2)]-D-threopentulose) from dimethyl 2,3-O-isopropylidene-o-tartrate (2) (44% overall yield) is described. The key-operation is a novel one-pot reductive alkylation of the protected halfester 3, by sequential treatment with superdeuteride(hydride) and methyl lithium, providing the protected 1-deoxy-D-xylulose (5) in high yield. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：6913 / 6914

页数：2

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