Appending a tris-imidazole ligand with a Tyr244 mimic on the distal face of bromoacetamidoporphyrin

被引：26

作者：

Collman, JP ^{[1
]}

Decréau, RA ^{[1
]}

Costanzo, S ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1021/ol049912m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromoacetamidoporphyrin is a convenient synthon for the attachment of distal superstructures at room temperature in good yields. New models are presented that contain a tris-imidazole distal ligand set bound to the porphyrin in either a binary or trinary fashion. More importantly, one distal imidazole is cross-linked to a phenol mimicking Tyr(244), making this model the closest structural analogue yet reported of the metal free cytochrome c oxidase (CcO) active site.

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页码：1033 / 1036

页数：4

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