The systems containing clays and clay minerals from modified drug release: A review

被引：139

作者：

de Sousa Rodrigues, Luis Alberto ^{[1
]}

Figueiras, Ana ^{[3
]}

Veiga, Francisco ^{[3
]}

de Freitas, Rivelilson Mendes ^{[1
]}

Cunha Nunes, Livio Cesar ^{[1
]}

da Silva Filho, Edson Cavalcanti ^{[2
]}

da Silva Leite, Cleide Maria ^{[1
]}

机构：

[1] Univ Fed Piaui, Ctr Ciencias Saude, Programa Posgrad Ciencias Farmaceut, BR-64049550 Teresina, PI, Brazil

[2] Univ Fed Piaui, Ctr Ciencias Nat, Programa Posgrad Ciencias Mat, BR-64049550 Teresina, PI, Brazil

[3] Univ Coimbra, Fac Farm, Coimbra, Portugal

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 103卷

关键词：

Clay; Clay mineral; Composite; Nanocomposite; Modified delivery drug system; LAYERED DOUBLE HYDROXIDES; IN-VITRO RELEASE; DELIVERY SYSTEM; SILICATE NANOCOMPOSITES; SUSTAINED-RELEASE; ANIONIC CLAYS; INTERCALATION COMPOUNDS; TETRACYCLINE-HCL; ORAL DELIVERY; MONTMORILLONITE;

D O I：

10.1016/j.colsurfb.2012.10.068

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Clays are materials commonly used in the pharmaceutical industry, either as ingredients or as active ingredients. It was observed that when they are administered concurrently, they may interact with drugs reducing their absorption. Therefore, such interactions can be used to achieve technological and biopharmaceutical advantages, regarding the control of release. This review summarizes bibliographic (articles) and technological (patents) information on the use of systems containing clays and clay minerals in modified drug delivery. In this area, formulations such natural clay, commercial clay, synthetic clay, composites clay-polymers, nanocomposites clay-polymers, films and hidrogels composites clay-polymers are used to slow/extend or vectorize the release of drugs and consequently they increase their bioavailability. Finally, this review summarizes the fields of technology and biopharmaceutical applications, where clays are applied. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：642 / 651

页数：10

共 119 条

[1]

Use of clays as drug delivery systems: Possibilities and limitations [J].