The Proteasome and its Role in the Degradation of Oxidized Proteins

被引：128

作者：

Jung, Tobias ^{[1
]}

Grune, Tilman ^{[1
]}

机构：

[1] Univ Hohenheim, Inst Biol Chem & Nutr, D-70593 Stuttgart, Germany

来源：

IUBMB LIFE | 2008年 / 60卷 / 11期

关键词：

proteasome; oxidative stress; reactive oxygen species;

D O I：

10.1002/iub.114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidized proteins have to be removed in order to prevent serious metabolic disturbances. The most important cellular proteolytic system responsible for the removal of oxidized proteins is the proteasomal system. For normal functioning the proteasomal system needs the coordinated interaction of numerous components. This review describes the fundamental functions of the 20S "core" proteasome. its regulators, and the roles of the proteasomal system beyond the removal of oxidized proteins in mammalian Cells. (C) 2008 IUBMB

引用

页码：743 / 752

页数：10

共 134 条

[21] The ubiquitin system: From basic mechanisms to the patient bed [J].