GABA, a forgotten gliotransmitter

被引：98

作者：

Angulo, Maria Cecilia ^{[2
]}

Le Meur, Karim ^{[2
]}

Kozlov, Andrei S. ^{[3
,4
]}

Charpak, Serge ^{[2
]}

Audinat, Etienne ^{[1
,2
]}

机构：

[1] Univ Paris 05, INSERM, U603, F-75006 Paris, France

[2] CNRS, UMR 8154, Paris, France

[3] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

[4] Rockefeller Univ, Lab Sensory Neurosci, New York, NY 10021 USA

来源：

PROGRESS IN NEUROBIOLOGY | 2008年 / 86卷 / 03期

关键词：

Glial cell; GABA; Neuron-glia interaction; Astrocyte;

D O I：

10.1016/j.pneurobio.2008.08.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The amino acid gamma-aminobutiric acid (GABA) is a major inhibitory transmitter in the vertebrate central nervous system (CNS) where it can be released by neurons and by giial cells. Neuronal GABAergic signaling is well characterized: the mechanisms of GABA release, the receptors it targets and the functional consequences of their activation have been extensively studied. In contrast, the corresponding features of glial GABAergic signaling have attracted less attention. In this review, we first discuss evidence from the literature for GABA accumulation, production and release by glial cells. We then review the results of recent experiments that point toward functional roles of GABA as a "gliotransmitter". (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：297 / 303

页数：7

相关论文

共 59 条

[1]

GAT-1 and reversible GABA transport in Bergmann glia in slices [J].

Barakat, L ;

Bordey, A .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (03) :1407-1419

[2]

ION CHANNEL EXPRESSION BY WHITE MATTER GLIA - THE O-2A GLIAL PROGENITOR-CELL [J].

BARRES, BA ;

KOROSHETZ, WJ ;

SWARTZ, KJ ;

CHUN, LLY ;

COREY, DP .

NEURON, 1990, 4 (04) :507-524

[3]

Selective neuroinhibitory effects of taurine in slices of rat main olfactory bulb [J].

Belluzzi, O ;

Puopolo, M ;

Benedusi, M ;

Kratskin, I .

NEUROSCIENCE, 2004, 124 (04) :929-944

[4]

Glutamic acid decarboxylase-positive neuronal cell bodies and terminals in the human cerebellar cortex [J].

Benagiano, V ;

Virgintino, D ;

Rizzi, A ;

Flace, P ;

Troccoli, V ;

Bormann, J ;

Monaghan, P ;

Robertson, D ;

Roncali, L ;

Ambrosi, G .

HISTOCHEMICAL JOURNAL, 2000, 32 (09) :557-564

[5]

LIGHT AND ELECTRON-MICROSCOPIC IMMUNOHISTOCHEMICAL DEMONSTRATION OF GABA-IMMUNOREACTIVE ASTROCYTES IN THE BRAIN-STEM OF THE RAT [J].

BLOMQVIST, A ;

BROMAN, J .

JOURNAL OF NEUROCYTOLOGY, 1988, 17 (05) :629-637

[6]

Synaptic release generates a tonic GABAA receptor-mediated conductance that modulates burst precision in thalamic relay neurons [J].

Bright, Damian P. ;

Aller, M. Isabel ;

Brickley, Stephen G. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (10) :2560-2569

[7]

Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains [J].

Bushong, EA ;

Martone, ME ;

Jones, YZ ;

Ellisman, MH .

JOURNAL OF NEUROSCIENCE, 2002, 22 (01) :183-192

[8]

THE ASTROCYTE RESPONSE TO GAMMA-AMINOBUTYRIC-ACID ATTENUATES WITH AGE IN THE RAT OPTIC-NERVE [J].

BUTT, AM ;

JENNINGS, J .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 258 (1351) :9-15

[9]

RESPONSE OF ASTROCYTES TO GAMMA-AMINOBUTYRIC-ACID IN THE NEONATAL RAT OPTIC-NERVE [J].

BUTT, AM ;

JENNINGS, J .

NEUROSCIENCE LETTERS, 1994, 168 (1-2) :53-56

[10]

Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices [J].

Cavelier, P ;

Attwell, D .

JOURNAL OF PHYSIOLOGY-LONDON, 2005, 564 (02) :397-410

← 1 2 3 4 5 6 →