Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking

被引：135

作者：

Ambroggi, Frederic ^{[1
,2
]}

Turiault, Marc ^{[3
,4
]}

Milet, Aude ^{[3
,4
]}

Deroche-Gamonet, Veronique ^{[1
,2
]}

Parnaudeau, Sebastien ^{[3
,4
,5
]}

Balado, Eric ^{[1
,2
]}

Barik, Jacques ^{[3
,4
,5
]}

van der Veen, Rixt ^{[1
,2
]}

Maroteaux, Gregoire ^{[3
,4
]}

Lemberger, Thomas ^{[6
]}

Schuetz, Guenther ^{[6
]}

Lazar, Monique ^{[3
,4
]}

Marinelli, Michela ^{[1
,2
]}

Piazza, Pier Vincenzo ^{[1
,2
]}

Tronche, Francois ^{[3
,4
,5
]}

机构：

[1] INSERM, NeuroCtr Magendie Pathophysiol Addict, U862, F-33077 Bordeaux, France

[2] Univ Bordeaux, F-33077 Bordeaux, France

[3] CNRS, UMR7148, F-75231 Paris 5, France

[4] Coll France, Inst Biol, F-75231 Paris 5, France

[5] CNRS, UMR7224, F-75252 Paris 05, France

[6] German Canc Res Ctr, D-69120 Heidelberg, Germany

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 03期

关键词：

SUBSTANCE USE DISORDERS; ANXIETY; EXPRESSION; GENE;

D O I：

10.1038/nn.2282

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.

引用

页码：247 / 249

页数：3

共 15 条

[1] Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness [J].

Boyle, MP ;

Kolber, BJ ;

Vogt, SK ;

Wozniak, DF ;

Muglia, LJ .

JOURNAL OF NEUROSCIENCE, 2006, 26 (07) :1971-1978

[2] Stress and the brain:: From adaptation to disease [J].

de Kloet, ER ;

Joëls, M ;

Holsboer, F .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (06) :463-475

[3]

Deroche-Gamonet V, 2003, J NEUROSCI, V23, P4785

[4] The relationship between anxiety and substance use disorders among individuals with severe affective disorders [J].

Goodwin, RD ;

Stayner, DA ;

Chinman, MJ ;

Wu, P ;

Tebes, JK ;

Davidson, L .

COMPREHENSIVE PSYCHIATRY, 2002, 43 (04) :245-252

[5] The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation [J].

Groc, Laurent ;

Choquet, Daniel ;

Chaouloff, Francis .

NATURE NEUROSCIENCE, 2008, 11 (08) :868-870

[6] Plasticity of reward neurocircuitry and the 'dark side' of drug addiction [J].

Koob, GF ;

Le Moal, M .

NATURE NEUROSCIENCE, 2005, 8 (11) :1442-1444

[7] Expression of Cre recombinase in dopaminoceptive neurons [J].

Lemberger, Thomas ;

Parlato, Rosanna ;

Dassesse, Donald ;

Westphal, Magdalena ;

Casanova, Emilio ;

Turiault, Marc ;

Tronche, Francois ;

Schiffmann, Serge N. ;

Schuetz, Guenther .

BMC NEUROSCIENCE, 2007, 8 (1)

[8]

Marinelli M, 2000, J NEUROSCI, V20, P8876

[9] Comorbidity of substance use disorders with mood and anxiety disorders: Results of the International Consortium in Psychiatric Epidemiology [J].

Merikangas, KR ;

Mehta, RL ;

Molnar, BE ;

Walters, EE ;

Swendsen, JD ;

Aguilar-Gaziola, S ;

Bijl, R ;

Borges, G ;

Caraveo-Anduaga, JJ ;

Dewit, DJ ;

Kolody, B ;

Vega, WA ;

Wittchen, HU ;

Kessler, RC .

ADDICTIVE BEHAVIORS, 1998, 23 (06) :893-907

[10] The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids [J].

Revest, JM ;

Di Blasi, F ;

Kitchener, P ;

Rougé-Pont, F ;

Desmedt, A ;

Turiault, M ;

Tronche, F ;

Piazza, PV .

NATURE NEUROSCIENCE, 2005, 8 (05) :664-672

← 1 2 →