The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation

被引：205

作者：

Groc, Laurent ^{[1
]}

Choquet, Daniel ^{[1
]}

Chaouloff, Francis ^{[2
]}

机构：

[1] Univ Bordeaux 2, CNRS, UMR 5091, F-33077 Bordeaux, France

[2] Univ Bordeaux 2, INSERM, U862, Equipe AVENIR Mecan Mol Adaptat, F-33077 Bordeaux, France

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 08期

关键词：

D O I：

10.1038/nn.2150

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.

引用

页码：868 / 870

页数：3

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