Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

被引：311

作者：

Groc, L

Heine, M

Cognet, L

Brickley, K

Stephenson, FA

Lounis, B

Choquet, D ^{[1
]}

机构：

[1] Univ Bordeaux 2, CNRS, UMR 5091, F-33077 Bordeaux, France

[2] CNRS, UMR 5798, Talence, France

[3] Univ London, Sch Pharm, London WC1N 1AX, England

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nn1270

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.

引用

页码：695 / 696

页数：2

共 13 条

[1] Regulation of AMPA receptor lateral movements [J].