Surface mobility of postsynaptic AMPARs tunes synaptic transmission

被引：368

作者：

Heine, Martin ^{[1
]}

Groc, Laurent ^{[1
]}

Frischknecht, Renato ^{[4
]}

Beique, Jean-Claude ^{[3
]}

Lounis, Brahim ^{[2
]}

Rumbaugh, Gavin ^{[3
]}

Huganir, Richard L. ^{[3
]}

Cognet, Laurent ^{[2
]}

Choquet, Daniel ^{[1
]}

机构：

[1] Univ Bordeaux 1, CNRS, UMR 5091, Bordeaux, France

[2] Univ Bordeaux 1, Ctr Phys Mol Opt & Hertzienne, CNRS, F-33405 Talence, France

[3] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD USA

[4] Leibniz Inst Neurobiol, Magdeburg, Germany

来源：

SCIENCE | 2008年 / 320卷 / 5873期

关键词：

D O I：

10.1126/science.1152089

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naive functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.

引用

页码：201 / 205

页数：5

共 37 条

[1] Photoinactivation of native AMPA receptors reveals their real-time trafficking [J].