Interleukin 6 and tumour necrosis factor alpha serum levels in monoclonal gammopathy of undetermined significance

被引：7

作者：

Bladé, J

Filella, X

Montoto, S

Bosch, F

Rosiñol, L

Coca, F

Giné, E

Nadal, E

Aymerich, M

Rozman, M

Montserrat, E

机构：

[1] Hosp Clin Barcelona, Postgrad Sch Hematol Farreras Valenti, Dept Hematol, Inst Hematol & Oncol, E-08036 Barcelona, Spain

[2] Univ Barcelona, IDIBAPS, Dept Biochem, Barcelona, Spain

[3] Univ Barcelona, Hosp Clin, Barcelona, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 117卷 / 02期

关键词：

IL-6; TNF-alpha; monoclonal gammopathy; malignant transformation; multiple myeloma;

D O I：

10.1046/j.1365-2141.2002.03424.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objectives of the present study were to compare the interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) serum levels of individuals with monoclonal gammopathy of undetermined significance (MGUS) with those of healthy controls, and to ascertain the predictor value of these cytokines in the evolution from MGUS to multiple myeloma. After a median follow-up of 7 years from the initial cytokine measurements, nine patients with MGUS have evolved to a malignant condition. The actuarial probability of malignant transformation in patients with increased IL-6 and TNF-alpha was not significantly higher than in those with normal values.

引用

页码：387 / 389

页数：3