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Epigenetics and aging

被引：59
作者：
D'Aquila, Patrizia [1 ]
Rose, Giuseppina [1 ]
Bellizzi, Dina [1 ]
Passarino, Giuseppe [1 ]
机构：
[1] Univ Calabria, Dept Cell Biol, I-87036 Arcavacata Di Rende, Italy
来源：
MATURITAS | 2013年 / 74卷 / 02期
关键词：
Epigenetics; Aging; Age-related diseases; Mitochondrial DNA; NON-CPG METHYLATION; DNA METHYLATION; MITOCHONDRIAL-DNA; GENE-EXPRESSION; LIFE-SPAN; HISTONE MODIFICATIONS; CONSERVED ROLE; AGE; MECHANISMS; METHYLTRANSFERASES;
D O I：
10.1016/j.maturitas.2012.11.005
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
030301 [社会学]; 100201 [内科学];
摘要：
Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks, such as DNA methylation and numerous histone modifications, are emerging as important factors of the overall variation in life expectancy. In fact, epigenetic marks, that are responsible of the establishment of specific expression programs and of genome stability, represent a "drawbridge" across genetic, environmental and stochastic factors. In this review we provide an overview on the current knowledge and the general features of the epigenetic modifications characterizing the aging process. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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页码：130 / 136
页数：7
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