Interleukin-2 in the pathogenesis of perinatal white matter damage

被引：63

作者：

Kadhim, H

Tabarki, B

De Prez, C

Rona, AM

Sébire, G

机构：

[1] Univ Catholique Louvain, Lab Neurol Dev, NEPE, B-1200 Brussels, Belgium

[2] ULB, CHU Brugmann HUDERF, Unite Neuropathol, Brussels, Belgium

[3] ULB, CHU Brugmann HUDERF, Serv Anatomopathol, Brussels, Belgium

来源：

NEUROLOGY | 2002年 / 58卷 / 07期

关键词：

D O I：

10.1212/WNL.58.7.1125

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin,. could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.

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页码：1125 / 1128

页数：4

相关论文

共 10 条

[1] Recombinant human IL-2 is cytotoxic to oligodendrocytes after in vitro self aggregation [J].

Curatolo, L ;

Valsasina, B ;

Caccia, C ;

Raimondi, GL ;

Orsini, G ;

Bianchetti, A .

CYTOKINE, 1997, 9 (10) :734-739

[2] A TRANSGLUTAMINASE THAT CONVERTS INTERLEUKIN-2 INTO A FACTOR CYTOTOXIC TO OLIGODENDROCYTES [J].

EITAN, S ;

SCHWARTZ, M .

SCIENCE, 1993, 261 (5117) :106-108

[3] APPEARANCE OF CYTOKINE-ASSOCIATED CENTRAL-NERVOUS-SYSTEM MYELIN DAMAGE COINCIDES TEMPORALLY WITH SERUM TUMOR-NECROSIS-FACTOR INDUCTION AFTER RECOMBINANT INTERLEUKIN-2 INFUSION IN RATS [J].

ELLISON, MD ;

MERCHANT, RE .

JOURNAL OF NEUROIMMUNOLOGY, 1991, 33 (03) :245-251

[4] Interleukin-2 as a neuroregulatory cytokine [J].

Hanisch, UK ;

Quirion, R .

BRAIN RESEARCH REVIEWS, 1995, 21 (03) :246-284

[5] Inflammatory cytokines in the pathogenesis of periventricular leukomalacia [J].

Kadhim, H ;

Tabarki, B ;

Verellen, G ;

De Prez, C ;

Rona, AM ;

Sébire, G .

NEUROLOGY, 2001, 56 (10) :1278-1284

[6] Multiple cerebral lesions complicating therapy with interleukin-2 [J].

Karp, BI ;

Yang, JC ;

Khorsand, M ;

Wood, R ;

Merigan, TC .

NEUROLOGY, 1996, 47 (02) :417-424

[7] CEREBRAL-PALSY [J].

KUBAN, KCK ;

LEVITON, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (03) :188-195

[8] Neonatal cytokines and coagulation factors in children with cerebral palsy [J].

Nelson, KB ;

Dambrosia, JM ;

Grether, JK ;

Phillips, TM .

ANNALS OF NEUROLOGY, 1998, 44 (04) :665-675

[9]

VECHT CJ, 1990, NEW ENGL J MED, V323, P1146

[10]

Volpe J., 1995, NEUROLOGY NEWBORN