Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells

被引：85

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Asano, T ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 09期

关键词：

D O I：

10.1021/np9901837

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new triterpene saponins (8 and 9) and seven previously reported triterpene saponins (1-7) based upon oleanolic acid or hederagenin, along with two known lignans, (+)-pinoresinol (10) and beta-peltatin (11), were isolated from a saponin fraction prepared from the MeOH extract of the roots of Pulsatilla chinensis. The structures of the new saponins were determined by spectroscopic analysis, including 2D NMR spectroscopic techniques, and the results of hydrolytic cleavage. The isolated compounds and some derivatives were evaluated for their cytotoxic activity against HL-60 human leukemia cells.

引用

页码：1279 / 1283

页数：5

共 13 条

[1] NMR-SPECTROSCOPY IN THE STRUCTURAL ELUCIDATION OF OLIGOSACCHARIDES AND GLYCOSIDES [J].

AGRAWAL, PK .

PHYTOCHEMISTRY, 1992, 31 (10) :3307-3330

[2] ARYLTETRALIN LIGNANS FROM LINUM-FLAVUM AND LINUM-CAPITATUM [J].

BROOMHEAD, AJ ;

DEWICK, PM .

PHYTOCHEMISTRY, 1990, 29 (12) :3839-3844

[3] TRITERPENOID GLYCOSIDES FROM THE ROOTS OF PATRINIA-SCABIOSAEFOLIA [J].

CHOI, JS ;

WOO, WS .

PLANTA MEDICA, 1987, (01) :62-65

[4] SAPONINS FROM COLLINSONIA-CANADENSIS [J].

JOSHI, BS ;

MOORE, KM ;

PELLETIER, SW ;

PUAR, MS ;

PRAMANIK, BN .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (10) :1468-1476

[5]

KANG S S, 1989, Archives of Pharmacal Research (Seoul), V12, P42, DOI 10.1007/BF02855745

[6] Steroidal glycosides from the bulbs of Allium jesdianum [J].

Mimaki, Y ;

Kuroda, M ;

Fukasawa, T ;

Sashida, Y .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :194-197

[7] TIGOGENIN HEXASACCHARIDES FROM CAMASSIA-CUSICKII - STRUCTURAL ELUCIDATION BY MODERN NMR TECHNIQUES [J].

MIMAKI, Y ;

SASHIDA, Y ;

NIKAIDO, T ;

OHMOTO, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1992, 65 (02) :458-462

[8] STUDIES ON CHINESE CRUDE DRUG FORSYTHIAE-FRUCTUS .1. CONSTITUENTS OF FORSYTHIAE-FRUCTUS ON MARKET [J].

NISHIBE, S ;

CHIBA, M ;

HISADA, S .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1977, 97 (10) :1134-1137

[9] SAPONINS FROM THE LEAVES OF ARALIA-ELATA SEEM (ARALIACEAE) [J].

SAITO, S ;

SUMITA, S ;

TAMURA, N ;

NAGAMURA, Y ;

NISHIDA, K ;

ITO, M ;

ISHIGURO, I .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (02) :411-414

[10] APPRAISAL OF THE MTT ASSAY AS A RAPID TEST OF CHEMOSENSITIVITY IN ACUTE MYELOID-LEUKEMIA [J].

SARGENT, JM ;

TAYLOR, CG .

BRITISH JOURNAL OF CANCER, 1989, 60 (02) :206-210

← 1 2 →