Steroidal glycosides from the bulbs of Allium jesdianum

被引：52

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Fukasawa, T ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980346b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical analysis of the fresh bulbs of Allium jesdianum yielded four steroidal glycosides, (22S)-cholest-5-ene-1 beta, 3 beta,16 beta,22-tetrol 1,16- di-O-beta-D-glucopyranoside (1), (22S)-cholest-5-ene-1 beta,3 beta,16 beta,22-tetrol 1-O-alpha-L-rhamnopyranosyl 16-O-beta-D-glucopyranoside (2), (25R)-5 alpha-spirostane-2 alpha,3 beta-diol 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside} (F-gitonin) (3), and (25R)-5 alpha-spirostane-2 alpha,3 beta,6 alpha-triol 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside} (4). Compound 2 is a new natural product, and 4 is a new spirostanol saponin. Compound 3 was found to exhibit cytostatic and cytotoxic activities against several malignant tumor cells.

引用

页码：194 / 197

页数：4

共 19 条

[1] Hostettmann K., 1995, SAPONINS
[2] STEROIDAL GLYCOSIDES FROM ALLIUM-MACLEANII AND A-SENESCENS, AND THEIR INHIBITORY ACTIVITY ON TUMOR PROMOTER-INDUCED PHOSPHOLIPID-METABOLISM OF HELA-CELLS
INOUE, T
MIMAKI, Y
SASHIDA, Y
NISHINO, A
SATOMI, Y
NISHINO, H
[J]. PHYTOCHEMISTRY, 1995, 40 (02) : 521 - 525
[3] KAWASAKI T, 1964, CHEM PHARM BULL, V12, P1311
[4] STEROIDAL SAPONINS FROM THE BULBS OF ALLIUM-SCHUBERTII
KAWASHIMA, K
MIMAKI, Y
SASHIDA, Y
[J]. PHYTOCHEMISTRY, 1993, 32 (05) : 1267 - 1272
[5] STEROIDAL SAPONINS FROM ALLIUM-GIGANTEUM AND ALLIUM-AFLATUNENSE
KAWASHIMA, K
MIMAKI, Y
SASHIDA, Y
[J]. PHYTOCHEMISTRY, 1991, 30 (09) : 3063 - 3067
[6] KAWASHIMA K, 1991, CHEM PHARM BULL, V39, P2761, DOI 10.1248/cpb.39.2761
[7] STEROIDAL SAPONINS FROM ALLIUM CHINENSE AND THEIR INHIBITORY ACTIVITIES ON CYCLIC-AMP PHOSPHODIESTERASE AND NA+/K+ ATPASE
KURODA, M
MIMAKI, Y
KAMEYAMA, A
SASHIDA, Y
NIKAIDO, T
[J]. PHYTOCHEMISTRY, 1995, 40 (04) : 1071 - 1076
[8] STEROID SAPONINS
MAHATO, SB
GANGULY, AN
SAHU, NP
[J]. PHYTOCHEMISTRY, 1982, 21 (05) : 959 - 978
[9] MIMAKI Y, 1994, CHEM PHARM BULL, V42, P710, DOI 10.1248/cpb.42.710
[10] Steroidal saponins from the rhizomes of Hosta sieboldii and their cytostatic activity on HL-60 cells
Mimaki, Y
Kuroda, M
Kameyama, A
Yokosuka, A
Sashida, Y
[J]. PHYTOCHEMISTRY, 1998, 48 (08) : 1361 - 1369

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