学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审
PI3K-PKB/Akt Pathway
被引:967
作者
:
Hemmings, Brian A.
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hemmings, Brian A.
[
1
]
Restuccia, David F.
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Restuccia, David F.
[
1
]
机构
:
[1]
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
来源
:
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
|
2012年
/ 4卷
/ 09期
关键词
:
PROTEIN-KINASE;
AKT;
AKT/PKB;
PHOSPHORYLATION;
RICTOR;
ALPHA;
D O I
:
10.1101/cshperspect.a011189
中图分类号
:
Q2 [细胞生物学];
学科分类号
:
071013
[干细胞生物学]
;
摘要
:
[No abstract available]
引用
收藏
页数:3
相关论文
共 13 条
[1]
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
[J].
Alessi, DR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Alessi, DR
;
论文数:
引用数:
h-index:
机构:
James, SR
;
论文数:
引用数:
h-index:
机构:
Downes, CP
;
Holmes, AB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Holmes, AB
;
Gaffney, PRJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Gaffney, PRJ
;
Reese, CB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Reese, CB
;
论文数:
引用数:
h-index:
机构:
Cohen, P
.
CURRENT BIOLOGY,
1997,
7
(04)
:261
-269
[2]
Discovery of PDKI, one of the missing links in insulin signal transduction
[J].
Alessi, DR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Dundee, Sch Life Sci, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Univ Dundee, Sch Life Sci, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Alessi, DR
.
BIOCHEMICAL SOCIETY TRANSACTIONS,
2001,
29
:1
-14
[3]
Perturbations of the AKT signaling pathway in human cancer
[J].
Altomare, DA
论文数:
0
引用数:
0
h-index:
0
机构:
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Altomare, DA
;
Testa, JR
论文数:
0
引用数:
0
h-index:
0
机构:
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Testa, JR
.
ONCOGENE,
2005,
24
(50)
:7455
-7464
[4]
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
[J].
Andjelkovic, M
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Andjelkovic, M
;
Jakubowicz, T
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Jakubowicz, T
;
Cron, P
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Cron, P
;
Ming, XF
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Ming, XF
;
Han, JW
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Han, JW
;
Hemmings, BA
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Hemmings, BA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1996,
93
(12)
:5699
-5704
[5]
PIKKing on PKB: regulation of PKB activity by phosphorylation
[J].
论文数:
引用数:
h-index:
机构:
Bozulic, Lana
;
Hemmings, Brian A.
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hemmings, Brian A.
.
CURRENT OPINION IN CELL BIOLOGY,
2009,
21
(02)
:256
-261
[6]
Ten years of protein kinase B signalling: a hard Akt to follow
[J].
Brazil, DP
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Brazil, DP
;
Hemmings, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Hemmings, BA
.
TRENDS IN BIOCHEMICAL SCIENCES,
2001,
26
(11)
:657
-664
[7]
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
[J].
Brognard, John
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Brognard, John
;
Sierecki, Emma
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Sierecki, Emma
;
Gao, Tianyan
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Gao, Tianyan
;
Newton, Alexandra C.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Newton, Alexandra C.
.
MOLECULAR CELL,
2007,
25
(06)
:917
-931
[8]
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
[J].
Feng, JH
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Feng, JH
;
Park, J
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Park, J
;
Cron, P
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Cron, P
;
Hess, D
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hess, D
;
Hemmings, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hemmings, BA
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004,
279
(39)
:41189
-41196
[9]
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
[J].
Guertin, David A.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Guertin, David A.
;
Stevens, Deanna M.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Stevens, Deanna M.
;
Thoreen, Carson C.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Thoreen, Carson C.
;
Burds, Aurora A.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Burds, Aurora A.
;
Kalaany, Nada Y.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Kalaany, Nada Y.
;
Moffat, Jason
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Moffat, Jason
;
Brown, Michael
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Brown, Michael
;
Fitzgerald, Kevin J.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Fitzgerald, Kevin J.
;
Sabatini, David M.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Sabatini, David M.
.
DEVELOPMENTAL CELL,
2006,
11
(06)
:859
-871
[10]
AKT/PKB signaling: Navigating downstream
[J].
Manning, Brendan D.
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
Manning, Brendan D.
;
Cantley, Lewis C.
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
Cantley, Lewis C.
.
CELL,
2007,
129
(07)
:1261
-1274
←
1
2
→
共 13 条
[1]
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
[J].
Alessi, DR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Alessi, DR
;
论文数:
引用数:
h-index:
机构:
James, SR
;
论文数:
引用数:
h-index:
机构:
Downes, CP
;
Holmes, AB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Holmes, AB
;
Gaffney, PRJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Gaffney, PRJ
;
Reese, CB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
Reese, CB
;
论文数:
引用数:
h-index:
机构:
Cohen, P
.
CURRENT BIOLOGY,
1997,
7
(04)
:261
-269
[2]
Discovery of PDKI, one of the missing links in insulin signal transduction
[J].
Alessi, DR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Dundee, Sch Life Sci, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Univ Dundee, Sch Life Sci, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Alessi, DR
.
BIOCHEMICAL SOCIETY TRANSACTIONS,
2001,
29
:1
-14
[3]
Perturbations of the AKT signaling pathway in human cancer
[J].
Altomare, DA
论文数:
0
引用数:
0
h-index:
0
机构:
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Altomare, DA
;
Testa, JR
论文数:
0
引用数:
0
h-index:
0
机构:
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA
Testa, JR
.
ONCOGENE,
2005,
24
(50)
:7455
-7464
[4]
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
[J].
Andjelkovic, M
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Andjelkovic, M
;
Jakubowicz, T
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Jakubowicz, T
;
Cron, P
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Cron, P
;
Ming, XF
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Ming, XF
;
Han, JW
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Han, JW
;
Hemmings, BA
论文数:
0
引用数:
0
h-index:
0
机构:
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
Hemmings, BA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1996,
93
(12)
:5699
-5704
[5]
PIKKing on PKB: regulation of PKB activity by phosphorylation
[J].
论文数:
引用数:
h-index:
机构:
Bozulic, Lana
;
Hemmings, Brian A.
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hemmings, Brian A.
.
CURRENT OPINION IN CELL BIOLOGY,
2009,
21
(02)
:256
-261
[6]
Ten years of protein kinase B signalling: a hard Akt to follow
[J].
Brazil, DP
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Brazil, DP
;
Hemmings, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Friedrich Miescher Inst, CH-4058 Basel, Switzerland
Hemmings, BA
.
TRENDS IN BIOCHEMICAL SCIENCES,
2001,
26
(11)
:657
-664
[7]
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
[J].
Brognard, John
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Brognard, John
;
Sierecki, Emma
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Sierecki, Emma
;
Gao, Tianyan
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Gao, Tianyan
;
Newton, Alexandra C.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
Newton, Alexandra C.
.
MOLECULAR CELL,
2007,
25
(06)
:917
-931
[8]
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
[J].
Feng, JH
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Feng, JH
;
Park, J
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Park, J
;
Cron, P
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Cron, P
;
Hess, D
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hess, D
;
Hemmings, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
Hemmings, BA
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004,
279
(39)
:41189
-41196
[9]
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
[J].
Guertin, David A.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Guertin, David A.
;
Stevens, Deanna M.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Stevens, Deanna M.
;
Thoreen, Carson C.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Thoreen, Carson C.
;
Burds, Aurora A.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Burds, Aurora A.
;
Kalaany, Nada Y.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Kalaany, Nada Y.
;
Moffat, Jason
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Moffat, Jason
;
Brown, Michael
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Brown, Michael
;
Fitzgerald, Kevin J.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Fitzgerald, Kevin J.
;
Sabatini, David M.
论文数:
0
引用数:
0
h-index:
0
机构:
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02141 USA
Sabatini, David M.
.
DEVELOPMENTAL CELL,
2006,
11
(06)
:859
-871
[10]
AKT/PKB signaling: Navigating downstream
[J].
Manning, Brendan D.
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
Manning, Brendan D.
;
Cantley, Lewis C.
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
Cantley, Lewis C.
.
CELL,
2007,
129
(07)
:1261
-1274
←
1
2
→