The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

被引：142

作者：

Lieber, MR

机构：

[1] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Pathol, Los Angeles, CA 90033 USA

[2] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA

[3] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

来源：

GENES TO CELLS | 1999年 / 4卷 / 02期

关键词：

D O I：

10.1046/j.1365-2443.1999.00245.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent progress over the past year has provided new insights into the proteins involved in nonhomologous end joining, The assembly of Ku and DNA-dependent protein kinase at DNA ends is now understood in greater detail. Murine genetic knockouts for DNA ligase TV and XRCC4 are embryonic lethal, indicating that nonhomologous end joining is essential for viability. Interestingly, neurones, in addition to lymphocytes, are particularly vulnerable to an absence of NHEJ.

引用

页码：77 / 85

页数：9

共 54 条

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