Genetic analysis of aging in Saccharomyces cerevisiae

被引：28

作者：

Kennedy, BK

Guarente, L

机构：

来源：

TRENDS IN GENETICS | 1996年 / 12卷 / 09期

关键词：

D O I：

10.1016/0168-9525(96)10039-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The natural limits to life span are poorly understood Yeast is a good model organism for studies of the aging process because single cells can be followed for many cell divisions and their loss of division potential follows kinetics identical to mortality rates in complex organisms. Recent experimental approaches ill yeast are beginning to lend to basic models of the factors that facilitate aging.

引用

收藏

页码：355 / 359

页数：5

相关论文

共 45 条

[11] EVIDENCE FOR THE INVOLVEMENT OF A CYTOPLASMIC FACTOR IN THE AGING OF THE YEAST SACCHAROMYCES-CEREVISIAE [J].

EGILMEZ, NK ;

JAZWINSKI, SM .

JOURNAL OF BACTERIOLOGY, 1989, 171 (01) :37-42

[12] PREPARATION AND PARTIAL CHARACTERIZATION OF OLD YEAST-CELLS [J].

EGILMEZ, NK ;

CHEN, JB ;

JAZWINSKI, SM .

JOURNALS OF GERONTOLOGY, 1990, 45 (01) :B9-B17

[13]

EGILMEZ NK, 1989, J BIOL CHEM, V264, P14312

[14] THE RNA COMPONENT OF HUMAN TELOMERASE [J].

FENG, JL ;

FUNK, WD ;

WANG, SS ;

WEINRICH, SL ;

AVILION, AA ;

CHIU, CP ;

ADAMS, RR ;

CHANG, E ;

ALLSOPP, RC ;

YU, JH ;

LE, SY ;

WEST, MD ;

HARLEY, CB ;

ANDREWS, WH ;

GREIDER, CW ;

VILLEPONTEAU, B .

SCIENCE, 1995, 269 (5228) :1236-1241

[15] REGULATION BY THE YEAST MATING-TYPE LOCUS OF STE12, A GENE REQUIRED FOR CELL-TYPE-SPECIFIC EXPRESSION [J].

FIELDS, S ;

HERSKOWITZ, I .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (10) :3818-3821

[16]

Gompertz B., 1825, Philos. Trans. Royal Soc. London B, Biol. Sci., V182, P513, DOI 10.1098/rstl.1825.0026

[17] TELOMERES SHORTEN DURING AGING OF HUMAN FIBROBLASTS [J].

HARLEY, CB ;

FUTCHER, AB ;

GREIDER, CW .

NATURE, 1990, 345 (6274) :458-460

[18] MUTANTS OF SACCHAROMYCES-CEREVISIAE UNRESPONSIVE TO CELL-DIVISION CONTROL BY POLYPEPTIDE MATING HORMONE [J].

HARTWELL, LH .

JOURNAL OF CELL BIOLOGY, 1980, 85 (03) :811-822

[19]

HARTWELL LH, 1977, J CELL BIOL, V75, P4522

[20] CLONING AND CHARACTERIZATION OF 4 SIR GENES OF SACCHAROMYCES-CEREVISIAE [J].

IVY, JM ;

KLAR, AJS ;

HICKS, JB .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (02) :688-702

← 1 2 3 4 5 →