The effects of APOE and tau gene variability on risk of frontotemporal dementia

Frontotemporal dementia (FTD) is a complex dementing syndrome whose genetic/non genetic risk factors are mostly unknown. Aim of the present work was to investigate whether APOE and/or tau gene variability does affect the risk of FTD. A sample of FTD cases (sporadic: n = 54; familial: n = 46, one subject per family) was collected in a genetically homogeneous population (Calabria, southern Italy) and analyzed in comparison with an age- and sex-matched control group (n = 180) extracted from the same population. Logistic regression analysis showed that APOE gene variability affects the probability of disease, with allele epsilon 4 increasing (exp((beta 1)) = 2.68 with [1.5 1-4.76] 95% confidence interval; p = 0.001) and allele epsilon 2 decreasing (exp((beta 1)) = 0.28 with [0.12-0.66] 95% confidence interval; p = 0.003) the risk of FrD. On the contrary, tau gene variability was ineffectual (exp((beta 1)) non significantly different from 1 for either H1 or H2 haplotypes), although a small effect was observed by the H I haplotype in increasing the protective effect of the epsilon 2 allele (p = 0.007). (c) 2005 Elsevier Inc. All rights reserved.