Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research

被引：322

作者：

Solanto, MV ^{[1
]}

机构：

[1] CUNY, Mt Sinai Med Ctr, Div Child & Adolescent Psychiat, New York, NY 10029 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2002年 / 130卷 / 1-2期

关键词：

attention-deficit hyperactivity disorder (ADHD); dopamine; methylphenidate; amphetamine; autoreceptors; prefrontal cortex; prefrontal-striatal-thalamic cortical circuit; striatum; attention; impulsivity; MRI; fMRI; PET; dopamine transporter (DAT); rate dependency;

D O I：

10.1016/S0166-4328(01)00431-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

There is strong evidence that the catecholamines dopamine and norepinephrine are both important in the pathophysiology of ADHD, as well as in the mechanism of therapeutic action of stimulant drugs. Due to the known effects of stimulants in blocking reuptake of catecholamines and (in the case Of D-amphetamine) facilitating their release, it has traditionally been believed that the stimulants compensate for catecholamine deficiency in ADHD. More recently, however, alternate hypotheses of a hyperdopaminergic and/or hyper-noradrenergic state in ADHD have been suggested. This paper will be limited to a review of the evidence for involvement of dopamine in mediating behavioral and cognitive symptoms and response to stimulants in ADHD, with implications for possible mechanisms, (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：65 / 71

页数：7

共 76 条

[31] STRAIN DIFFERENCES IN AMPHETAMINE SENSITIVITY IN MICE .1. DIALLEL ANALYSIS OF OPEN-FIELD ACTIVITY [J].

KITAHAMA, K ;

VALATX, JL .

PSYCHOPHARMACOLOGY, 1979, 66 (02) :189-194

[32] COGNITIVE EVENT-RELATED POTENTIALS IN ATTENTION-DEFICIT DISORDER [J].

KLORMAN, R .

JOURNAL OF LEARNING DISABILITIES, 1991, 24 (03) :130-140

[33] STIMULANT-DRUGS AND VIGILANCE PERFORMANCE - A REVIEW [J].

KOELEGA, HS .

PSYCHOPHARMACOLOGY, 1993, 111 (01) :1-16

[34] Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography [J].

Krause, KH ;

Dresel, SH ;

Krause, J ;

Kung, HF ;

Tatsch, K .

NEUROSCIENCE LETTERS, 2000, 285 (02) :107-110

[35]

LAHEY BB, 1994, AM J PSYCHIAT, V151, P1673

[36] Attention-deficit hyperactivity disorder: A category or a continuum? Genetic analysis of a large-scale twin study [J].

Levy, F ;

Hay, DA ;

McStephen, M ;

Wood, C ;

Waldman, I .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (06) :737-744

[37] THE ACTION OF STIMULANT MEDICATION IN ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY - DOPAMINERGIC, NORADRENERGIC, OR BOTH [J].

LEVY, F ;

HOBBES, G .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1988, 27 (06) :802-805

[38] Error patterns on the continuous performance test in non-medicated and medicated samples of children with and without ADHD: A meta-analytic review [J].

Losier, BJ ;

McGrath, PJ ;

Klein, RM .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 1996, 37 (08) :971-987

[39]

Mattay VS, 1996, J NEUROSCI, V16, P4816

[40] PERFORMANCE OF DISTURBED HYPERACTIVE AND NONHYPERACTIVE CHILDREN ON AN OBJECTIVE-MEASURE OF HYPERACTIVITY [J].

MCCLURE, FD ;

GORDON, M .

JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 1984, 12 (04) :561-571

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