Ruthenium-Catalyzed Direct Methylation of Primary and Secondary Aromatic Amines Using Carbon Dioxide and Molecular Hydrogen

被引：221

作者：

Beydoun, Kassem ^{[1
]}

vom Stein, Thorsten ^{[1
]}

Klankermayer, Juergen ^{[1
]}

Leitner, Walter ^{[1
,2
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Tech & Makromol Chem, D-52074 Aachen, Germany

[2] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 36期

关键词：

carbon dioxide; homogeneous catalysis; hydrogenation; methylation; ruthenium; NMR-SPECTROSCOPY; HOMOGENEOUS HYDROGENATION; FORMIC-ACID; CO2; METHANOL; LIGANDS; TRANSFORMATION; CHEMISTRY; RELEVANCE; FORMATES;

D O I：

10.1002/anie.201304656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effective catalytic N-methylation of anilines using CO2 as C1 source and molecular hydrogen as reducing agent was demonstrated using the well-defined [Ru(triphos)(tmm)] catalyst. Secondary and primary (shown) aromatic amines were mono- or dialkylated, respectively, in high yields. N-methylation of amides coupled with the amide hydrogenation offers an efficient approach to unsymmetrical tertiary methyl/alkyl/aromatic amines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9554 / 9557

页数：4

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