Novel reaction products from thiobarbituric acid of biological interest

被引：12

作者：

Aly, AA

Mourad, AFE ^{[1
]}

Hassan, AA

Mohamed, NK

Ali, BA

El-Sayed, MM

机构：

[1] El Menia Univ, Fac Sci, Dept Chem, El Minia 61519, Egypt

[2] Menia Univ, Fac Pharm, Dept Med Chem, El Minia, Egypt

来源：

ARCHIV DER PHARMAZIE | 2004年 / 337卷 / 03期

关键词：

thiobarbituric acid; pi-deficients; biological activity;

D O I：

10.1002/ardp.200300802

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The reactions of 1,2-dihydro-2-thioxo-4,6(1H,5H)pyrimidinedione (1) with some pi-deficients have led to the formation of unexpected heterocyclic products such as anilinomethylenethioxopyrimidinedione, 2,2'-bis(pyrimidinecarbothioamide), allylthioxopyrimidinecarbothioamide, indenopyranopyrimidine and benzofuropyrimidine derivatives. A possible mechanism for the formation of these products is discussed, and the biological activity is determined.

引用

页码：133 / 139

页数：7

共 58 条

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[2]

ABDELLATIF FF, 1993, Z NATURFORSCH B, V48, P817

[3]

Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents [J].