Ethanol dosage regimes in studies of ethanol toxicity: Influence of nutrition and surgical interventions

被引:35
作者
Preedy, VR [1 ]
McIntosh, A [1 ]
Bonner, AB [1 ]
Peters, TJ [1 ]
机构
[1] ROEHAMPTON INST,ADDICT BEHAV CTR,TISSUE PATHOL UNIT,LONDON,ENGLAND
关键词
D O I
10.1080/1355621961000124866
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this review we consider some of the practical facets of acute and chronic drug regimes. In particular, we illustrate our arguments with specific reference to alcohol and-draw attention to methodological constraints that might alter biochemical or physiological processes. These includes the imposition of nutritional abnormalities and surgical procedures. These two areas are highlighted because there is evidence to show that they have marked influences on metabolic parameters, exemplified by tissue protein synthesis. In general, there is no controversy as to methods for acute studies with alcohol, although some reports have failed to investigate whether intravenous, intragastric or intraperitoneal regimes move accurately mimic the clinical situation. With regard to chronic feeding regimes, evidence is provided to support the argument that, currently, the most appropriate feeding protocol ensures that both control and treated groups receive identical amounts of nutrients albeit with differences in the calories apportioned to ethanol, which is substituted by isocaloric glucose or other carbohydrates in controls. However, there are still other methods being employed: these are subject to misinterpretation as the principle of ensuring that control and ethanol-fed rats receive identical amounts of nutrients, is ignored. In this review we also draw attention to the fact that surgical procedures, which are often employed to facilitate the measurement of body parameters (for example, implantation of cannulae), themselves alter tissue metabolism. The importance of this relates to the concept of metabolic superimposition, which implicates interacting responses when two or more stresses (i.e. surgery and drug administration) are superimposed.
引用
收藏
页码:255 / 262
页数:8
相关论文
共 47 条
[31]   THE EFFECTS OF SURGICAL STRESS AND SHORT-TERM FASTING ON PROTEIN-SYNTHESIS INVIVO IN DIVERSE TISSUES OF THE MATURE RAT [J].
PREEDY, VR ;
PASKA, L ;
SUGDEN, PH ;
SCHOFIELD, PS ;
SUGDEN, MC .
BIOCHEMICAL JOURNAL, 1988, 250 (01) :179-188
[32]   ACUTE ETHANOL DOSAGE REDUCES THE SYNTHESIS OF SMOOTH-MUSCLE CONTRACTILE PROTEINS IN THE SMALL-INTESTINE OF THE RAT [J].
PREEDY, VR ;
DUANE, P ;
PETERS, TJ .
GUT, 1988, 29 (09) :1244-1248
[33]   ACUTE EFFECTS OF ETHANOL ON PROTEIN-SYNTHESIS IN DIFFERENT MUSCLES AND MUSCLE PROTEIN-FRACTIONS OF THE RAT [J].
PREEDY, VR ;
PETERS, TJ .
CLINICAL SCIENCE, 1988, 74 (05) :461-466
[34]   THE EFFECT OF CHRONIC ETHANOL INGESTION ON PROTEIN-METABOLISM IN TYPE-I-FIBER-RICH AND TYPE-II-FIBER-RICH SKELETAL-MUSCLES OF THE RAT [J].
PREEDY, VR ;
PETERS, TJ .
BIOCHEMICAL JOURNAL, 1988, 254 (03) :631-639
[35]   ETHANOL-INDUCED SMOOTH AND SKELETAL-MUSCLE MYOPATHY - USE OF ANIMAL STUDIES [J].
PREEDY, VR ;
MARWAY, JS ;
MACPHERSON, AJS ;
PETERS, TJ .
DRUG AND ALCOHOL DEPENDENCE, 1990, 26 (01) :1-8
[36]  
PREEDY VR, 1988, ALCOHOL ALCOHOLISM, V23, P151
[37]   URINARY-EXCRETION OF NITROGENOUS AND NONNITROGENOUS COMPOUNDS IN THE CHRONIC ETHANOL-FED RAT [J].
PREEDY, VR ;
HAMMOND, B ;
ILES, RA ;
DAVIES, SEC ;
GANDY, JD ;
CHALMERS, RA ;
PETERS, TJ .
CLINICAL SCIENCE, 1991, 80 (04) :393-400
[38]  
SHERLOCK S, 1984, LANCET, V1, P436
[39]   ANIMAL-MODELS OF ALCOHOLIC LIVER-DISEASE [J].
SIMPSON, KJ ;
PETERS, TJ .
BAILLIERES CLINICAL GASTROENTEROLOGY, 1993, 7 (03) :609-625
[40]   TIME DEPENDENCY OF IGA NEPHROPATHY INDUCTION IN ALCOHOL INGESTION [J].
SMITH, SM ;
TSUKAMOTO, H .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1992, 16 (03) :471-473