RNA interference directs innate immunity against viruses in adult Drosophila

被引：565

作者：

Wang, XH

Aliyari, R

Li, WX

Li, HW

Kim, K

Carthew, R

Atkinson, P

Ding, SW ^{[1
]}

机构：

[1] Univ Calif Riverside, Grad Program Microbiol, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Dept Plant Pathol, Riverside, CA 92521 USA

[3] Univ Calif Riverside, Ctr Plant Cell Biol, Inst Integrat Genome Biol, Riverside, CA 92521 USA

[4] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA

[5] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

SCIENCE | 2006年 / 312卷 / 5772期

关键词：

D O I：

10.1126/science.1125694

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Innate immunity against bacterial. and fungal pathogens is mediated by Toll. and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which Viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

引用

页码：452 / 454

页数：3

共 18 条

[11] R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway [J].