Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 Central and Eastern European countries

被引：30

作者：

Nagai, K

Appelbaum, PC ^{[1
]}

Davies, TA

Kelly, LM

Hoellman, DB

Tambic Andrasevic, A

Drukalska, L

Hryniewicz, W

Jacobs, MR

Kolman, J

Miciuleviciene, J

Pana, M

Setchanova, L

Thege, MK

Hupkova, H

Trupl, J

Urbaskova, P

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, 500 Univ Dr, Hershey, PA 17033 USA

[2] Sera & Vaccine Lab, Warsaw, Poland

[3] Med Acad Latvia, Childrens Hosp, Riga, Latvia

[4] Univ Zagreb, Hosp Infect Dis, Zagreb 41000, Croatia

[5] Case Western Reserve Univ, Cleveland, OH 44106 USA

[6] Univ Ljubljana, Ljubljana, Slovenia

[7] Kaunas Med Univ Hosp, Kaunas, Lithuania

[8] Inst Cantacuzino, Bucharest, Romania

[9] Acad Med Sofia, Hosp Infect Dis, Sofia, Bulgaria

[10] Natl Ctr Epidemiol, Budapest, Hungary

[11] St Cyril & Method Hosp, Bratislava, Slovakia

[12] Natl Canc Inst, Bratislava, Slovakia

[13] Natl Antibiot Reference Lab, Prague, Czech Republic

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期

关键词：

D O I：

10.1128/AAC.46.2.546-549.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among 1,011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC(50)s) and the MIC(90)s were as follows: for telithromycin, 0.03 and 0.06 mug/ml, respectively; for erythromycin, azithromycin, and clarithromyrin, 0.06 to 0.125 and 1 to 8 mug/ml, respectively; and for clindamycin, 0.125 and 0.125 mug/ml, respectively. Erythromycin resistance occurred in 12 3 % of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 mug/ml, telithromycin was active against 98.5% of the strains tested.

引用

页码：546 / 549

页数：4

共 25 条

[1] High prevalence of erythromycin-resistant, clindamycin/miocamycin-susceptible (M phenotype) Streptococcus pyogenes:: results of a Spanish multicentre study in 1998 [J].