Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis

被引：12

作者：

Caton, Paul W. ^{[1
]}

Evans, Elizabeth A. ^{[1
]}

Philpott, Michael P. ^{[2
]}

Hannen, Rosalind F. ^{[2
]}

机构：

[1] Kings Coll London, Div Diabet & Nutr Sci, London SE1 91UL, England

[2] Queen Mary Univ London, Blizard Inst, Ctr Cell Biol & Cutaneous Res, London E1 2AT, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2017年 / 37卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

CATHELICIDIN ANTIMICROBIAL PEPTIDE; INSULIN-RESISTANCE; DIABETES-MELLITUS; INFLAMMATION; OBESITY; CELL; PSORIASIS; DYSFUNCTION; DISEASE; MICE;

D O I：

10.1016/j.coph.2017.08.011

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Prevalence of obesity and related complications such as type 2 diabetes (T2D) has increased dramatically in recent decades. Metabolic complications of obesity arise in part due to subcutaneous adipose tissue (SAT) dysfunction. However, it is currently unclear why some obese individuals develop insulin resistance and T2D and others do not. In this review, we discuss the role of the skin in regulating SAT function, and whether presence of inflammatory skin diseases such as psoriasis represent a novel risk mechanism mediating development of obesity-related complications.

引用

页码：59 / 64

页数：6

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