Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

被引：544

作者：

Ali, Niwa ^{[1
,3
]}

Zirak, Bahar ^{[1
]}

Rodriguez, Robert Sanchez ^{[1
]}

Pauli, Mariela L. ^{[1
]}

Hong-An Truong ^{[1
]}

Lai, Kevin ^{[1
]}

Ahn, Richard ^{[1
]}

Corbin, Kaitlin ^{[2
]}

Lowe, Margaret M. ^{[1
]}

Scharschmidt, Tiffany C. ^{[1
]}

Taravati, Keyon ^{[1
]}

Tan, Madeleine R. ^{[1
]}

Ricardo-Gonzalez, Roberto R. ^{[1
]}

Nosbaum, Audrey ^{[1
]}

Bertolini, Marta ^{[4
]}

Liao, Wilson ^{[1
]}

Nestle, Frank O. ^{[3
]}

Paus, Ralf ^{[5
,6
]}

Cotsarelis, George ^{[7
]}

Abbas, Abul K. ^{[2
]}

Rosenblum, Michael D. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[3] Kings Coll London, St Johns Inst Dermatol, Cutaneous Med Unit, London WC2R 2LS, England

[4] Univ Munster, Dept Dermatol, D-48149 Munster, Germany

[5] Univ Manchester, Ctr Dermatol Res, Manchester M13 9PL, Lancs, England

[6] NIHR Manchester Biomed Res Ctr, Manchester M13 9PL, Lancs, England

[7] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA

来源：

CELL | 2017年 / 169卷 / 06期

关键词：

HAIR FOLLICLE BULGE; DENDRITIC CELLS; SELF-RENEWAL; IN-VITRO; HOMEOSTASIS; POPULATION; RESIDENT; JAGGED-1; INHIBIT; INNATE;

D O I：

10.1016/j.cell.2017.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregs and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.

引用

页码：1119 / +

页数：22

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