Reversal of diabetes in non-obese diabetic mice without spleen cell-derived β cell regeneration

被引：100

作者：

Chong, AS

Shen, JK

Tao, J

Yin, DP

Kuznetsov, A

Hara, M

Philipson, LH

机构：

[1] Univ Chicago, Dept Surg, Sect Transplantat, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Endocrinol Sect, Chicago, IL 60637 USA

[3] Univ Illinois, Dept Surg, Chicago, IL 60612 USA

来源：

SCIENCE | 2006年 / 311卷 / 5768期

关键词：

D O I：

10.1126/science.1123510

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Autoimmune destruction of beta cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although beta cells in these mice were not derived from donor splenocytes.

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页码：1774 / 1775

页数：2

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