Immunological reversal of autoimmune diabetes without hematopoietic replacement of β cells

被引：83

作者：

Suri, A ^{[1
]}

Calderon, B ^{[1
]}

Esparza, TJ ^{[1
]}

Frederick, K ^{[1
]}

Bittner, P ^{[1
]}

Unanue, ER ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

SCIENCE | 2006年 / 311卷 / 5768期

关键词：

D O I：

10.1126/science.1123500

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type 1 diabetes mellitus results from the autoimmune destruction of the beta cells of the pancreatic islets of Langerhans and is recapitulated in the nonobese diabetic strain of mice. In an attempt to rescue islet loss, diabetic mice were made normoglycemic by islet transplantation and immunization with Freund's complete adjuvant along with multiple injections of allogeneic mate splenocytes. This treatment allowed for survival of transplanted islets and recovery of endogenous beta cell function in a proportion of mice, but with no evidence for allogeneic splenocyte-derived differentiation of new islet beta cells. Control of the autoimmune disease at a crucial time in diabetogenesis can result in recovery of beta cell function.

引用

页码：1778 / 1780

页数：3

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