Signaling routes to CREM and CREB: plasticity in transcriptional activation

被引：203

作者：

De Cesare, D ^{[1
]}

Fimia, GM ^{[1
]}

Sassone-Corsi, P ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(99)01414-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinases stimulated by cyclic AMP, Ca2+, growth factors and stress signals. Phosphorylation allows recruitment of CREB-binding protein (CBP), a large co-activator that contacts the general transcriptional machinery. Studies of the physiological roles played by CREB and CREM have uncovered novel routes of transcriptional activation. For example, in male germ cells CREM is not phosphorylated but associates with ACT, a member of the LIM-only class of proteins that has intrinsic transcriptional activity. Thus, in some circumstances, CREM can bypass the classical requirement for phosphorylation and association with CBP.

引用

页码：281 / 285

页数：5