Cortico-spinal pathways and inhibitory mechanisms in hepatic encephalopathy

被引:26
作者
Nolano, M
Guardascione, MA
Amitrano, L
Perretti, A
Fiorillo, F
Ascione, A
Santoro, L
Caruso, G
机构
[1] UNIV NAPLES FEDERICO II,NEUROL CLIN 2,DIPARTIMENTO SCI NEUROL,NUOVO POLICLIN,I-80131 NAPLES,ITALY
[2] IRCCS,FDN SALVATORE MAUGERI,CAMPOLI MONTE TAB,BN,ITALY
[3] A CARDARELLI HOSP,LIVER PATHOPHYSIOL UNIT,NAPLES,ITALY
来源
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1997年 / 105卷 / 01期
关键词
motor evoked potentials; silent period; hepatic encephalopathy; liver cirrhosis;
D O I
10.1016/S0924-980X(96)96571-6
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Transcranial magnetic stimulation of the cerebral cortex was used to study motor system function in 31 cirrhotics (29 post-necrotic and 2 cryptogenic) with and without hepatic encephalopathy (HE). The results were compared with those of 14 healthy subjects matched for age. A significant increase of central motor conduction time, a significant raising of the motor evoked potential (MEP) threshold at rest and a significant reduction of the MEP/muscle action potential (MAP) amplitude ratio were found only in patients with chronic stable (12 patients) and recurrent (9 patients) HE. Vice versa, a significant shortening of the central silent period was observed in all 31 cirrhotic patients. The peripheral silent period was normal in all instances. These results indicate that the damage to the cortico-spinal pathways is related to the progression of cirrhosis to HE, and that cirrhotic patients present a dysfunction of the inhibitory motor mechanisms before HE is clinically manifest. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:72 / 78
页数:7
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