Catalytic asymmetric Pictet-Spengler reaction

被引：416

作者：

Seayad, J ^{[1
]}

Seayad, AM ^{[1
]}

List, B ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 04期

关键词：

D O I：

10.1021/ja057444l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic asymmetric Pictet-Spengler reaction has been developed, wherein treating substituted tryptamines with an aldehyde in the presence of a catalytic amount of a chiral phosphoric acid provides the corresponding tetrahydro-β-carboline derivatives in high yields and enantiomeric excesses. The reaction works well with both aliphatic and aromatic aldehydes. Copyright © 2006 American Chemical Society.

引用

页码：1086 / 1087

页数：2

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