Correlation between the photostability and photodynamic efficacy for different photosensitizers

被引：31

作者：

Ferreira, J

Kurachi, C

Moriyama, LT

Menezes, PFC

Perussi, JR

Sibata, C

Zucoloto, S

Silva, OC

Bagnato, VS ^{[1
]}

机构：

[1] USP, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil

[2] USP, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil

[3] USP, Inst Quim Sao Carlos, Sao Carlos, SP, Brazil

[4] E Carolina Univ, Brody Sch Med, Greenville, SC USA

来源：

LASER PHYSICS LETTERS | 2006年 / 3卷 / 02期

关键词：

photodynamic therapy; photobleaching; photo-destruction of tissue;

D O I：

10.1002/lapl.200510057

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Using three haematoporphyrin based photosensitizers we investigating their. properties related to the phototransformation in solution, the inhibitory concentration (IC50) in cell culture and the threshold dose (D-th) in rat livers. The observation of such properties shows the existence of a strong correlation among them. The photosensitizer with the highest phototransformation rate is also, he one with the lowest Dth and IC50, showing more efficacy in cell killing and tissue necrosis during photodynamic therapy applications. We discuss this explanation for such correlation and the possible practical applications for this property.

引用

页码：91 / 95

页数：5

共 23 条

[1] Photosensitizers in clinical PDT [J].