A chemoenzymatic preparation of both enantiomers of omega-hydroxymethyl-substitute lactones

被引：16

作者：

Buisson, D

Azerad, R

机构：

[1] Laboratoire de Chimie, Biochim. Pharmacologiques T., Univ. Rene Descartes-Paris V, 75270-Paris Cedex 06

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 01期

关键词：

D O I：

10.1016/0957-4166(95)00408-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R)- and (S)-delta-hydroxymethyl vaterolactone and epsilon-hydroxymethyl caprolactone were prepared as tert-butyldiphenylsilyl derivatives, in good yields and high enantiomeric purities, in a 5 step sequence, starting from the microbial stereospecific reduction of ethyl 2-oxocyclopentane or 2-oxocyclohexane carboxylates respectively.

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页码：9 / 12

页数：4

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