Life-on-a-chip

被引：132

作者：

Lidstrom, ME ^{[1
]}

Meldrum, DR ^{[1
]}

机构：

[1] Univ Washington, Microscale Life Sci Ctr, Seattle, WA 98195 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2003年 / 1卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrmicro755

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mechanistic studies of cellular processes are usually carried out with large populations of cells. However, parameters that are measured as averages of large populations can be misleading. For instance, an apparently linear response to a signal could, in fact, reflect an increasing number of cells in the population that have switched from 'off' to 'on', rather than a graded increase in response by all the cells. At present, the study of single cells is challenging, but new technologies mean it might soon be a reality.

引用

页码：158 / 164

页数：7

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