Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles

被引：195

作者：

Hwang, Dae Kun ^{[1
]}

Dendukuri, Dhananjay ^{[1
]}

Doyle, Patrick S. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

LAB ON A CHIP | 2008年 / 8卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1039/b805176c

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Spherical and non-spherical magnetic hydrogel particles were synthesized in a microfluidic device containing an embedded UV light reflector. Monodisperse magnetic emulsion droplets were generated in a T-junction and allowed to relax into spheres, disks, and plugs in confining microchannel geometries. Particle morphology was locked-in via UV-initiated photopolymerization. The role of the reflector in the microchannel is to provide a uniform distribution of UV energy to the magnetic emulsion droplets and to increase the UV flux, which significantly improves UV polymerization conditions for microfluidic-based particle synthesis. Magnetic nanoparticles were uniformly encapsulated in the hydrogel, giving the microparticles superparamagnetic behavior. Additionally, the non-spherical particles show anisotropic responses under an applied external magnetic field.

引用

页码：1640 / 1647

页数：8

共 65 条

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