Special article "Green Banana" -: Sarcopenia ≠ dynapenia

被引:653
作者
Clark, Brian C. [1 ]
Manini, Todd M. [2 ]
机构
[1] Ohio Univ, Dept Biomed Sci, Coll Osteopath Med, Interdisciplinary Inst Neuromusculoskeletal Res, Athens, OH 45701 USA
[2] Univ Florida, Coll Med, Inst Aging, Dept Aging & Geriatr Res, Gainesville, FL 32611 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2008年 / 63卷 / 08期
关键词
aging; strength; atrophy; sarcopenia; dynapenia;
D O I
10.1093/gerona/63.8.829
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Maximal voluntary force (strength) production declines with age and contributes to physical dependence and mortality. Consequently, a great deal of research has focused on identifying strategies to maintain muscle Mass during the aging process and elucidating key molecular pathways of atrophy, with the rationale that the loss of strength is primarily a direct result of the age-associated declines in mass (sarcopenia). However, recent evidence questions this relationship and in this Green Banana article we argue the role of sarcopenia in mediating the age-associated loss of strength (which we will coin as dynapenia) does not deserve the attention it has attracted in both the scientific literature and popular press. Rather, we propose that alternative mechanisms underlie dynapenia (i.e., alterations in contractile properties or neurologic function), and urge that greater attention be paid to these variables in determining their role in dynapenia.
引用
收藏
页码:829 / 834
页数:6
相关论文
共 40 条
  • [1] Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process
    Adamo, Martin L.
    Farrar, Roger P.
    [J]. AGEING RESEARCH REVIEWS, 2006, 5 (03) : 310 - 331
  • [2] [Anonymous], 1623, CYMBERLINE
  • [3] Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Bhasin, S
    Woodhouse, L
    Casaburi, R
    Singh, AB
    Mac, RP
    Lee, M
    Yarasheski, KE
    Sinha-Hikim, I
    Dzekov, C
    Dzekov, J
    Magliano, L
    Storer, TW
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (02) : 678 - 688
  • [4] Chen H., 2006, GERONTOLOGIST, V46, P153
  • [5] Doublet discharges in motoneurons of young and older adults
    Christie, A
    Kamen, G
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2006, 95 (05) : 2787 - 2795
  • [6] Adaptations in human neuromuscular function following prolonged unweighting: II. Neurological properties and motor imagery efficacy
    Clark, Brian C.
    Manini, Todd M.
    Bolanowski, Stanley J.
    Ploutz-Snyder, Lori L.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2006, 101 (01) : 264 - 272
  • [7] Neural control of aging skeletal muscle
    Delbono, O
    [J]. AGING CELL, 2003, 2 (01) : 21 - 29
  • [8] Delbono O, 2000, J Nutr Health Aging, V4, P162
  • [9] WHAT IS SARCOPENIA
    EVANS, WJ
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 : 5 - 8
  • [10] A CROSS-SECTIONAL STUDY OF MUSCLE STRENGTH AND MASS IN 45-YEAR-OLD TO 78-YR-OLD MEN AND WOMEN
    FRONTERA, WR
    HUGHES, VA
    LUTZ, KJ
    EVANS, WJ
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1991, 71 (02) : 644 - 650