Quantitative analysis of the sensitivity of porous silicon optical biosensors

被引:135
作者
Ouyang, H [1 ]
Striemer, CC
Fauchet, PM
机构
[1] Univ Rochester, Dept Elect & Comp Engn, Rochester, NY 14620 USA
[2] Univ Rochester, Ctr Future Hlth, Rochester, NY 14620 USA
基金
美国国家科学基金会;
关键词
D O I
10.1063/1.2196069
中图分类号
O59 [应用物理学];
学科分类号
摘要
The optical response of porous silicon affinity biosensors depends strongly on their nanomorphology because the sensing species does not completely fill the pores but is instead attached to the pore walls. The performance and sensitivity of porous silicon microcavity biosensors are calculated as a function of pore size using a simplified effective medium approximation. Excellent agreement is obtained between the model predictions and the experimental results after binding of aminopropyltriethoxysilane and glutaraldehyde in mesoporous and macroporous silicon microcavities. Detection of layers thinner than 0.01 nm should be possible. (c) 2006 American Institute of Physics.
引用
收藏
页数:3
相关论文
共 19 条
[1]  
Canham Leigh., 1997, Properties of porous silicon
[2]   Nanoscale silicon microcavities for biosensing [J].
Chan, S ;
Li, Y ;
Rothberg, LJ ;
Miller, BL ;
Fauchet, PM .
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2001, 15 (1-2) :277-282
[3]   Identification of gram negative bacteria using nanoscale silicon microcavities [J].
Chan, S ;
Horner, SR ;
Fauchet, PM ;
Miller, BL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (47) :11797-11798
[4]   Tunable, narrow, and directional luminescence from porous silicon light emitting devices [J].
Chan, S ;
Fauchet, PM .
APPLIED PHYSICS LETTERS, 1999, 75 (02) :274-276
[5]   Biomolecular screening with encoded porous-silicon photonic crystals [J].
Cunin, F ;
Schmedake, TA ;
Link, JR ;
Li, YY ;
Koh, J ;
Bhatia, SN ;
Sailor, MJ .
NATURE MATERIALS, 2002, 1 (01) :39-41
[6]   A porous silicon optical biosensor: Detection of reversible binding of IgG to a protein A-modified surface [J].
Dancil, KPS ;
Greiner, DP ;
Sailor, MJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (34) :7925-7930
[7]   Monitoring penetration of ethanol in a porous silicon microcavity by photoluminescence interferometry [J].
Gaburro, Z ;
Daldosso, N ;
Pavesi, L ;
Faglia, G ;
Baratto, C ;
Sberveglieri, G .
APPLIED PHYSICS LETTERS, 2001, 78 (23) :3744-3746
[8]  
Hecht E., 1979, OPTICS
[9]  
Hermanson G. T., 1996, BIOCOJUGATE TECHNIQU
[10]  
Létant SE, 2001, ADV MATER, V13, P335, DOI 10.1002/1521-4095(200103)13:5<335::AID-ADMA335>3.0.CO