Ion channels and transporters in the development of drug resistance in cancer cells

被引:91
作者
Hoffmann, Else K. [1 ]
Lambert, Ian H. [1 ]
机构
[1] Univ Copenhagen, Dept Biol, DK-2100 Copenhagen O, Denmark
关键词
cancer; drug resistance; tumour proliferation; apoptosis; ion channels in cancer; CISPLATIN-INDUCED APOPTOSIS; CA2+-ACTIVATED CL-CHANNEL; MULTIDRUG-RESISTANCE; VOLUME REGULATION; BCL-2-DEPENDENT MODULATION; POTASSIUM CHANNELS; CA2+ HOMEOSTASIS; DOWN-REGULATION; OSMOTIC-STRESS; P-GLYCOPROTEIN;
D O I
10.1098/rstb.2013.0109
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis.
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页数:9
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