Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs

被引：10

作者：

Booth, Antonia E. G. ^{[2
]}

Seabra, Miguel C. ^{[2
,3
]}

Hume, Alistair N. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Biomed Sci, Nottingham NG7 2UH, England

[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[3] Univ Nova Lisboa, Fac Ciencias Med, CEDOC, P-1200 Lisbon, Portugal

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

melanocyte; melanosomes; Rab27a; Rab GTPase; NUCLEOTIDE-EXCHANGE FACTOR; GDP-DISSOCIATION INHIBITOR; LEGIONELLA-PNEUMOPHILA; FUNCTIONAL SPECIFICITY; PRENYLATED RAB; DENN DOMAIN; GTPASES; PROTEINS; EFFECTOR; COMPLEX;

D O I：

10.1042/BST20120200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Rab proteins constitute the largest family within the Ras superfamily of small GTPases (>60 in mammals) and are essential regulators of transport between intracellular organelles. Key to this activity is their targeting to specific compartments within the cell. However, although great strides have been made over the last 25 years in assigning functions to individual Rabs and identifying their downstream effectors, the mechanism(s) regulating their targeting to specific subcellular membranes remains less well understood. In the present paper, we review the evidence supporting the proposed mechanisms of Rab targeting and highlight insights into this process provided by studies of Rab27a.

引用

页码：1383 / 1388

页数：6

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