Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors

被引：62

作者：

Calero, M ^{[1
]}

Winand, NJ ^{[1
]}

Collins, RN ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Med, Ithaca, NY 14853 USA

来源：

FEBS LETTERS | 2002年 / 515卷 / 1-3期

基金：

美国国家科学基金会;

关键词：

Rab; YIP1; YIP4; YIP5; YGL198W; YGL161C;

D O I：

10.1016/S0014-5793(02)02442-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Rab GTPases are key regulators of membrane traffic. Yip1p is a membrane protein of unknown function that has been reported to interact with the Rabs Ypt1p and Ypt31p. In this study we identify Yif1p, and two unknown open reading frames, Yg1198p and Yg1161p, which we term Yip4p and Yip5p, as Yip1p-related sequences. We demonstrate that the Yip1p-related proteins possess several features: (i) they have a common overall domain topology, (ii) they are capable of biochemical interaction with a variety of Rab proteins in a manner dependent on C-terminal prenylation, and (iii) they share an ability to physically associate with other members of the YIP1 family. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：89 / 98

页数：10

共 24 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].