Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

被引：71

作者：

Alla, Mosaad S. M. Abd ^{[2
]}

Hegab, Mohamed I. ^{[1
]}

Taleb, Nageh A. Abo ^{[2
]}

Hasabelnaby, Sherifa M. ^{[2
]}

Goudah, A. ^{[3
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo 12622, Egypt

[2] Helwan Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Cairo, Egypt

[3] Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 04期

关键词：

1(2H)-Oxo-phthalazine; 1,3,4-Triazole; 1,3,4-Oxadiazole; 1,34-Thiadiazol; Pyrazole; Anti-inflammatory; SELECTIVE PDE4 INHIBITORS; CIS-HEXAHYDROPHTHALAZINONES; BIOLOGICAL EVALUATION; POTENT INHIBITORS; DERIVATIVES; POLY(ADP-RIBOSE)POLYMERASE; PHTHALAZINONES; SERIES; AGENTS;

D O I：

10.1016/j.ejmech.2009.10.028

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR. (1)H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin (R). (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：1267 / 1277

页数：11

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