Synthesis and biological activity evaluation of differently substituted 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides and -carbothioamides

被引：27

作者：

Cardia, MC

Distinto, S

Maccioni, E

Bonsignore, L

Delogu, A

机构：

[1] Univ Cagliari, Dipartimento Farmaco Chim Tecnol, I-09124 Cagliari, Italy

[2] Univ Cagliari, Dipartimento Sci & Tecnol Biomed, I-09123 Cagliari, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 40卷 / 06期

关键词：

D O I：

10.1002/jhet.5570400609

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Differently substituted phthalic anhydrides can react either with semicarbazide or thiosemicarbazide to give respectively 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides or 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carbothioamides under mild conditions and generally with good yields. These compounds have been tested in order to evaluate their anti-microbial activity. Furthermore a new synthetic pathway to phthalazino[2,3-b]phthalazine-5,7,12,14-tetraone has been devised.

引用

页码：1011 / 1015

页数：5

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