Bacterial cold-shock proteins

被引:187
作者
Ermolenko, DN
Makhatadze, GI [1 ]
机构
[1] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA
[2] Russian Acad Sci, AN Bach Inst Biochem, Moscow 117071, Russia
关键词
ssDNA/RNA binding protein; RNA chaperone; regulation of transcription; regulation of translation; bacterial cold shock; cold adaptation;
D O I
10.1007/PL00012513
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Members of a family of small cold-shock proteins (CSPs) are induced during bacterial cell response to a temperature decrease. Here we review available data about the structure, molecular properties, mechanism of induction and possible functions of CSPs. CSPs preferentially bind single-stranded RNA and DNA and appear to play an important role in cell physiology under both normal and cold-shock conditions. Although the function of CSPs in cold-shock adaptation has not yet been elucidated in detail, a number of experimental evidences suggests that CSPs bind messenger RNA (mRNA) and regulate ribosomal translation, rate of mRNA degradation and termination of transcription.
引用
收藏
页码:1902 / 1913
页数:12
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