Bacterial cold-shock proteins

被引：187

作者：

Ermolenko, DN

Makhatadze, GI ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA

[2] Russian Acad Sci, AN Bach Inst Biochem, Moscow 117071, Russia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 11期

关键词：

ssDNA/RNA binding protein; RNA chaperone; regulation of transcription; regulation of translation; bacterial cold shock; cold adaptation;

D O I：

10.1007/PL00012513

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of a family of small cold-shock proteins (CSPs) are induced during bacterial cell response to a temperature decrease. Here we review available data about the structure, molecular properties, mechanism of induction and possible functions of CSPs. CSPs preferentially bind single-stranded RNA and DNA and appear to play an important role in cell physiology under both normal and cold-shock conditions. Although the function of CSPs in cold-shock adaptation has not yet been elucidated in detail, a number of experimental evidences suggests that CSPs bind messenger RNA (mRNA) and regulate ribosomal translation, rate of mRNA degradation and termination of transcription.

引用

页码：1902 / 1913

页数：12

共 139 条

[91] Thermal stability and atomic-resolution crystal structure of the Bacillus caldolyticus cold shock protein [J].