Alzheimer's disease - The ins and outs of amyloid-beta

被引：43

作者：

Beyreuther, K ^{[1
]}

Masters, CL ^{[1
]}

机构：

[1] UNIV MELBOURNE, DEPT PATHOL, PARKVILLE, VIC 3025, AUSTRALIA

来源：

NATURE | 1997年 / 389卷 / 6652期

关键词：

D O I：

10.1038/39479

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The extracellular plaques of amyloid-b (Ab) peptide that form in the brains of pateints with Alzheimer's disease are thought to be involved in neurodegeneration but, until now, nobody was sure how Ab interfered with neuronal function. The finding that Ab interacts with the newly discovered endoplasmic-reticulum-associated binding protein (ERAB) in neurons may help to solve this puzzle.

引用

页码：677 / 678

页数：2

共 15 条

[11] alpha-synuclein in Lewy bodies
Spillantini, MG
Schmidt, ML
Lee, VMY
Trojanowski, JQ
Jakes, R
Goedert, M
[J]. NATURE, 1997, 388 (6645) : 839 - 840
[12] The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein
Tienari, PJ
DeStrooper, B
Ikonen, E
Simons, M
Weidemann, A
Czech, C
Hartmann, T
Ida, N
Multhaup, G
Masters, CL
VanLeuven, F
Beyreuther, K
Dotti, CG
[J]. EMBO JOURNAL, 1996, 15 (19) : 5218 - 5229
[13] Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
Tienari, PJ
Ida, N
Ikonen, E
Simons, M
Weidemann, A
Multhaup, G
Masters, CL
Dotti, CG
Beyreuther, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) : 4125 - 4130
[14] Yan SD, 1997, NATURE, V389, P689
[15] NEUROTOXICITY OF A FRAGMENT OF THE AMYLOID PRECURSOR ASSOCIATED WITH ALZHEIMERS-DISEASE
YANKNER, BA
DAWES, LR
FISHER, S
VILLAKOMAROFF, L
OSTERGRANITE, ML
NEVE, RL
[J]. SCIENCE, 1989, 245 (4916) : 417 - 420

← 1 2 →