Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis

被引：182

作者：

Li, Bin ^{[1
]}

Li, Weihong ^{[2
]}

Li, Xiaoli ^{[1
]}

Zhou, Hong ^{[1
]}

机构：

[1] Third Mil Med Univ, Coll Pharm, Dept Pharmacol, POB 400038, Chongqing 400038, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Assisted Reprod Ctr, Chongqing 400016, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 08期

关键词：

Atherosclerosis; inflammation; drug discovery; target identification; CORONARY-HEART-DISEASE; TOLL-LIKE RECEPTORS; FACTOR-KAPPA-B; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SELECTIN GLYCOPROTEIN LIGAND-1; HOMEOSTATIC CHEMOKINES CCL19; ACUTE MYOCARDIAL-INFARCTION; REGULATORY T-CELLS; PHOSPHOLIPASE A(2); DOUBLE-BLIND;

D O I：

10.2174/1381612822666161230142931

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatment targeting the inflammatory nature of atherosclerosis is still very limited and deserves further attention to fight atherosclerosis successfully. Here, we review the current development of inflammation and atherosclerosis to discuss novel insights and potential targets in atherosclerosis, and to address drug discovery based on anti-inflammatory strategy in atherosclerotic disease.

引用

页码：1216 / 1227

页数：12

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