Cell regulation: determined to signal discrete cooperation

被引:131
作者
Gibson, Toby J. [1 ]
机构
[1] European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany
关键词
MESSENGER-RNA TRANSPORT; SPATIAL REGULATION; INTRAFLAGELLAR TRANSPORT; PROTEIN-SYNTHESIS; NUCLEAR-ENVELOPE; MOLECULAR MOTORS; CARGO TRANSPORT; GLOBAL ANALYSIS; PHOSPHORYLATION; LOCALIZATION;
D O I
10.1016/j.tibs.2009.06.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Do kinases cascade? How well is cell regulation understood? What are the best ways to model regulatory systems? Attempts to answer such questions can have bearings on the way in which research is conducted. Fortunately there are recurring themes in regulatory processes from many different cellular contexts, which might provide useful guidance. Three principles seem to be almost universal: regulatory interactions are cooperative; regulatory decisions are made by large dynamic protein complexes; and regulation is intricately networked. A fourth principle, although not universal, is remarkably common: regulatory proteins are actively placed where they are needed. Here, I argue that the true nature of cell signalling and our perceptions of it are in a state of discord. This raises the question: Are our misconceptions detrimental to progress in biomedical science?
引用
收藏
页码:471 / 482
页数:12
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