Tracking the ends: a dynamic protein network controls the fate of microtubule tips

被引：764

作者：

Akhmanova, Anna ^{[1
]}

Steinmetz, Michel O. ^{[2
]}

机构：

[1] Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands

[2] Paul Scherrer Inst, CH-5232 Villigen, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 04期

关键词：

D O I：

10.1038/nrm2369

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. + TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.

引用

页码：309 / 322

页数：14

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