Tracking the ends: a dynamic protein network controls the fate of microtubule tips

被引：764

作者：

Akhmanova, Anna ^{[1
]}

Steinmetz, Michel O. ^{[2
]}

机构：

[1] Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands

[2] Paul Scherrer Inst, CH-5232 Villigen, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 04期

关键词：

D O I：

10.1038/nrm2369

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. + TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.

引用

页码：309 / 322

页数：14

共 128 条

[51] Identification of a link between the tumour suppressor APC and the kinesin superfamily [J].

Jimbo, T ;

Kawasaki, Y ;

Koyama, R ;

Sato, R ;

Takada, S ;

Haraguchi, K ;

Akiyama, T .

NATURE CELL BIOLOGY, 2002, 4 (04) :323-327

[52] Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis [J].

Kato, C ;

Miyazaki, K ;

Nakagawa, A ;

Ohira, M ;

Nakamura, Y ;

Ozaki, T ;

Imai, T ;

Nakagawara, A .

INTERNATIONAL JOURNAL OF CANCER, 2004, 112 (03) :365-375

[53] Assembly dynamics of microtubules at molecular resolution [J].

Kerssemakers, Jacob W. J. ;

Munteanu, E. Laura ;

Laan, Liedewij ;

Noetzel, Tim L. ;

Janson, Marcel E. ;

Dogterom, Marileen .

NATURE, 2006, 442 (7103) :709-712

[54] Microtubule binding by dynactin is required for microtubule organization but not cargo transport [J].

Kim, Hwajin ;

Ling, Shuo-Chien ;

Rogers, Gregory C. ;

Kural, Comert ;

Selvin, Paul R. ;

Rogers, Stephen L. ;

Gelfand, Vladimir I. .

JOURNAL OF CELL BIOLOGY, 2007, 176 (05) :641-651

[55] The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications [J].

Kim, MH ;

Cooper, DR ;

Oleksy, A ;

Devedjiev, Y ;

Derewenda, U ;

Reiner, O ;

Otlewski, J ;

Derewenda, ZS .

STRUCTURE, 2004, 12 (06) :987-998

[56] Adenomatous polyposis coli in cell extensions can promote with or without EB1 [J].

Kita, K ;

Wittmann, T ;

Näthke, IS ;

Waterman-Storer, CM .

MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (05) :2331-2345

[57] ACF7: An essential integrator of microtubule dynamics [J].

Kodama, A ;

Karakesisoglou, L ;

Wong, E ;

Vaezi, A ;

Fuchs, E .

CELL, 2003, 115 (03) :343-354

[58] EB1 and EB3 control CLIP dissociation from the ends of growing microtubules [J].

Komarova, Y ;

Lansbergen, G ;

Galjart, N ;

Grosveld, F ;

Borisy, GG ;

Akhmanova, A .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (11) :5334-5345

[59] Cytoplasmic linker proteins promote microtubule rescue in vivo [J].

Komarova, YA ;

Akhmanova, AS ;

Kojima, S ;

Galjart, N ;

Borisy, GG .

JOURNAL OF CELL BIOLOGY, 2002, 159 (04) :589-599

[60] Microtubule plus end: A hub of cellular activities [J].

Lansbergen, G ;

Akhmanova, A .

TRAFFIC, 2006, 7 (05) :499-507

← 1 2 3 4 5 6 7 8 9 10 →